Sex-related upregulation of bone morphogenetic protein signaling inhibits adult neurogenesis in APP^NL-G-F alzheimer's disease model mice.

ABSTRACT:

Background

Bone morphogenetic proteins (BMPs) have been reported in many studies to be related to adult neurogenesis. Neurogenic impairment is a hallmark of Alzheimer's disease (AD), while the involvement of BMPs remains unclear.

Methods

AD models were established using APP^NL-G-F transgenic mice and C57BL/6 mice subjected to intracerebral injection of Aβ_(25-35) peptide. Female APP^NL-G-F mice received pharmacological inhibitor treatment, whereas Neuro2a cells were exposed to estrogen stimulation in vitro. Immunofluorescence staining was conducted to evaluate hippocampal neural stem cell proliferation. The hippocampus and cellular pellets were isolated, and quantitative PCR (qPCR) was employed to determine mRNA expression levels.

Results

SUBMITTER: Su X 

PROVIDER: S-EPMC12699841 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature