The repertoire of short tandem repeats across the tree of life.

ABSTRACT:

Background

Short tandem repeats (STRs) are widespread, dynamic repetitive elements with a number of biological functions and relevance to human diseases, genome plasticity and adaptation. However, their prevalence across taxa remains poorly characterized.

Results

Here, we examined the prevalence and distribution of STRs across the complete genomes of 117,861 organisms spanning the tree of life. We find that there are large differences in the frequencies of STRs between organismal genomes, and these differences are largely driven by the taxonomic group an organism belongs to. Using simulated genomes, we find that on average, there is no enrichment of STRs in bacterial and archaeal genomes, suggesting that these genomes are not particularly repetitive. In contrast, we find tha

SUBMITTER: Chantzi N 

PROVIDER: S-EPMC12699852 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature