Phospholipid composition in small airway lining fluid among tunnel construction workers exposed to respirable crystalline silica.

ABSTRACT:

Objective

To explore if the phospholipid composition in the small airway lining fluid differed between a group of tunnel construction workers exposed to respirable crystalline silica (RCS) and a reference group.

Methods

In total, 19 healthy, non-smoking workers under exposure to RCS and 21 unexposed referents from the same construction site were included. The participants underwent a health examination including lung function measurements and collection of exhaled particles (PEx) using the Particles in exhaled air (PExA) method. Analysis of PEx included determination of lipids. In total, 95 lipid species, primarily phospholipids, were determined. Non-parametric analyses (Wilcoxon rank-sum test and quantile regression), principal component analysis (PCA) and orthogonal partia

SUBMITTER: Leite M 

PROVIDER: S-EPMC12699859 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature