Gut microbiota and intestinal polyps: a systematic review and meta-analysis based on 16S rRNA gene sequencing.

ABSTRACT:

Aim

Colorectal polyps serve as precursors to colorectal cancer and pose a growing public health challenge with their increasing incidence. The potential role of gut microbiota (GM) dysbiosis in colorectal polyp pathogenesis has garnered attention, yet existing evidence remains inconsistent. This study aimed to compare gut microbiota differences between colorectal polyp patients and healthy controls using systematic review and meta-analysis using 16S rRNA sequencing data.

Materials and methods

Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, a systematic search was performed across multiple databases (PubMed, Web of Science, Embase, Cochrane Library) up to April 2025. Only studies comparing gut microbiota profiles between colorectal

SUBMITTER: Wu Q 

PROVIDER: S-EPMC12699881 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature