The Role of microRNA-19b, microRNA-21, and microRNA-208a in diagnosis of heart failure.

ABSTRACT:

Background

Heart failure (HF) is a fast-growing public health concern that is linked to substantial morbidity and mortality as well as a poor quality of life. There is no specific biomarker that can be used to detect early HF with preserved ejection fraction (EF). MicroRNAs (miRs) are known to be involved in the development of HF.

Aim

To investigate the plasma level of miR-19b, miR-21, and miR-208a and their relevance in early diagnosis of HF.

Subjects and methods

In this study, 120 participants were divided into four groups: 30 controls in Group I, 30 HF patients with preserved EF in Group II, 30 HF patients with mildly reduced EF (HFmrEF) in Group III, and 30 HF patients with reduced EF (HFrEF) in Group IV. Real-time PCR was used to examine the expression levels of

SUBMITTER: Fathy WM 

PROVIDER: S-EPMC12699888 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature