Human eosinophils exert antitumorigenic effects on chordoma.

ABSTRACT:

Background

Chordoma is a devastating rare tumor with a poor prognosis, limited therapeutic options and a high recurrence rate. The exploration of novel therapeutic targets has important clinical significance in chordoma diagnosis, treatment, and outcome prediction.

Methods

In this study, chordoma patients with histopathologically verified disease and KI67 proliferation index data were enrolled. The peripheral eosinophil counts of chordoma patients were summarized, the antitumor effects of eosinophils against chordoma cells were investigated using a coculture experiment, and the potential mechanisms were analyzed.

Results

The chordoma patients were classified into two groups according to KI67 proliferation index: 1) ≤ 5% (n = 62), and 2) > 5% (n = 80). The results show

SUBMITTER: Ying W 

PROVIDER: S-EPMC12699895 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature