In vitro anti-diabetic activity and molecular docking studies of Amaranthus cruentus, Amaranthus hybridus and isolated compounds.

ABSTRACT:

Background

Amaranthus species are traditional leafy vegetable also reputed for their potential in managing metabolic disorders, including diabetes. In previous investigations conducted by our group, extracts from Amaranthus cruentus and Amaranthus hybridus, along with isolated compounds, exhibited strong α-glucosidase enzyme and moderate α-amylase inhibition in vitro.

Methods

The present study evaluated the antidiabetic effects of extracts and isolated compounds on C3A hepatocytes and L6 myoblasts. In addition, to elucidate the potential molecular mechanisms behind the observed enzymatic inhibition, we conducted docking studies of the isolated compounds against α-glucosidase and α-amylase. The finely powdered leaf samples were mixed with methanol and extracted using a cold m

SUBMITTER: Nkobole N 

PROVIDER: S-EPMC12699917 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature