FujiLAM assays for tuberculosis detection in people with HIV: a systematic review and meta-analysis.

ABSTRACT:

Background

There is a global need for a rapid, accurate, and non-sputum point-of-care (PoC) assay for tuberculosis (TB), especially for people with HIV (PLHIV). The Fujifilm SILVAMP TB LAM (FujiLAM), a urine lipoarabinomannan assay, has shown promise for diagnosing TB in PLHIV. But diagnostic performances were inconsistent across studies. This systematic review and meta-analysis aimed to determine the pooled sensitivity and specificity of FujiLAM for TB diagnosis in PLHIV.

Methods

A search was performed on August 10, 2025, across Scopus, PubMed, EMBASE, and Google Scholar using keywords including Fujifilm SILVAMP TB LAM, SILVAMP-LAM, FujiLAM, lipoarabinomannan test, Mycobacterium tuberculosis, tuberculosis, and TB. We included English-language studies that evaluated the Fuji

SUBMITTER: Taye B 

PROVIDER: S-EPMC12699939 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature