Tibetan herbal medicine <i>Oxytropis falcata</i> Bunge ameliorates hypoxic pulmonary hypertension in rats via regulation of intestinal microbiota and metabolites.

ABSTRACT:

Background

Hypoxic pulmonary hypertension (HPH) is a severe high-altitude disorder with limited therapeutic options. This study investigated the therapeutic mechanisms of Oxytropis falcata Bunge (OFB), a traditional Tibetan herbal medicine, in a rat model of HPH, focusing on its effects on endogenous metabolites and gut microbiota.

Methods

HPH was induced in male Sprague-Dawley rats exposed to chronic hypoxia. Animals were randomly assigned to normoxic control, hypoxic model, OFB-treated, or Rhodiola-treated groups. Serum metabolomics (LC-MS) and 16S rRNA sequencing of fecal microbiota were performed. Cardiopulmonary parameters including RVSP and RVHI were assessed, and pulmonary arterial ultrastructure was examined.

Results

OFB significantly attenuated HPH-ind

SUBMITTER: He Y 

PROVIDER: S-EPMC12700028 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature