Diet and the Risk of Multiple Sclerosis: Evidence With UK Biobank Nested Case-Control Study and Mendelian Randomization Analysis.

ABSTRACT: Genetic and environmental factors jointly affect the onset of multiple sclerosis (MS), among which diet holds considerable interest as a potentially modifiable factor. A nested case-control study was conducted, including 303 participants with MS and 1212 age- and sex-matched controls from the UK Biobank. Conditional logistic regression models were used to estimate the relationship between diet and MS. Mendelian randomization (MR) analysis was employed to examine the genetic associations between various food types and the risk of MS. Mediation analyses were performed to determine the possible mediating effect of serum measurements using the Karlson-Holm-Breen method. Participants who regularly consumed oily fish and consumed more bread per week had a decreased risk of MS. Increased consumpt

SUBMITTER: Chen L 

PROVIDER: S-EPMC12700044 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature