Peptides From Adzuki Bean and Soybean Improved Insulin-AKT Signaling-Related Pathways in Healthy and Insulin-Resistant States in Human Liver Cells.

ABSTRACT: The objectives were to determine the effect and mechanism of functional peptides identified from digested adzuki bean β-vignin and soybean β-conglycinin on insulin-AKT signaling and hepatic glucose uptake markers and to investigate the roles of these peptides in modulating the insulin-AKT signaling pathway in human liver cells in healthy and insulin-resistant states. Methods and Results: Adzuki bean β-vignin and soybean β-conglycinin proteins were isolated and digested using simulated gastrointestinal digestion. Peptide sequences (VP, PM, FNE, LLS, and IPA), in silico analysis and in vitro (cell-free and HepG2 cell-based) systems confirmed their safety and dipeptidyl peptidase IV (DPP IV) inhibitory capacity. IPA and VP showed high intestinal absorption and low toxicity, inhibited DPP IV (

SUBMITTER: Kwan SH 

PROVIDER: S-EPMC12700049 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature