The Nutrigenomic Effect of Mela Rosa Marchigiana Callus Extract on Cellular Senescence: Insight From a Preliminary In Vitro Study.

ABSTRACT: Mela Rosa Marchigiana (MRM) is an apple variety cultured in the center of Italy. Calluses derived from in vitro culture of MRM explants were used to obtain an ethanolic extract rich in pentacyclic triterpenic acids with putative anti-inflammatory and anti-aging effects. In this study, we investigated the transcriptomic and epigenetic effects of MRM callus extract (MRME) in an in vitro model of cellular senescence. Senescent HUVECs (sHUVECs) were treated with MRME. Transcriptomic analysis was performed to compare young HUVECs (yHUVECs) with sHUVECs and to evaluate the MRME's effect on sHUVECs. Results show that senescence induces major changes in the transcriptome of HUVECs. MRME downregulates TNF-α signaling genes in sHUVECs restoring the expression to that observed in yHUVECs. Genome-wide

SUBMITTER: Rucci C 

PROVIDER: S-EPMC12700053 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature