Connectivity and phenotype of vasopressin 1a receptor cells in the lateral septum.

ABSTRACT: The neuropeptide arginine-vasopressin (AVP) regulates sexually-differentiated social behaviors, including sexual behavior, aggression, and social communication. Much of AVP's effect on social behavior is mediated by the most widely-expressed AVP receptor in the central nervous system: the vasopressin 1a receptor (V1aR). Dense expression of V1aR is found in males and females in the lateral septum (LS), which also receives heavy input from sexually-differentiated populations of AVP cells in the extended amygdala. In order to access and interrogate the structure and function of V1aR cells, we developed and validated a V1aR-Cre knockin mouse line (Avpr1a-P2A-iCre). V1aR-Cre mice did not differ from their Cre-negative littermates in their health, sensorimotor function, anxiety/motivational beha

SUBMITTER: Hartswick D 

PROVIDER: S-EPMC12700077 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature