TSG-6 promotes healing of critical-sized bone defects in mice.

ABSTRACT: Tumor necrosis factor-stimulated gene 6 (TSG-6) is recognized for its anti-inflammatory and pro-regenerative properties in various inflammatory conditions, including peritonitis, arthritis, traumatic brain injury, and corneal as well as skin wound healing. However, its regenerative role in bone metabolism and repair remains largely unexplored. This study aimed to address this gap. We observed an increased expression of Tnfaip6 (Tsg-6) during early osteogenic differentiation of murine mesenchymal stem cells (mMSCs). Silencing Tnfaip6 significantly impaired osteogenic differentiation, as indicated by reduced alkaline phosphatase activity and downregulation of key osteogenic marker genes. RNA-seq analysis of Tnfaip6-deficient mMSCs revealed decreased expression of

SUBMITTER: Kuppers O 

PROVIDER: S-EPMC12700086 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature