A dynamic model of gene activation in response to hypoxia accounting for both HIF-1 and HIF-2.

ABSTRACT: We developed an ordinary differential equations (ODEs) model of hypoxia signaling that, in addition to HIF-1α, takes into account also HIF-2α. Our model can be separated into two parts, the first, describing the production and degradation of the α subunits of HIF-1 and HIF-2, and their accumulation in response to hypoxia; and the second, describing how the α subunits cooperate with the β subunit in binding to cis-regulatory regions and activation of HIF-target genes in response to hypoxia. In our previous work [1], using the first part of our model trained on time-series data from 0.9 % hypoxia, we successfully predicted the response of the system to a further drop of the oxygen to 0.3 % hypoxia. This modeling result contributed to explaining the mechanism of the switch of the control from

SUBMITTER: Cabaj A 

PROVIDER: S-EPMC12700088 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature