High Phosphate Load Induces De Novo Formation of Tertiary Lymphoid Structures in the Kidney.

ABSTRACT: Tertiary lymphoid structures (TLS) are associated with inflammatory kidney diseases, but their pathogenesis is unclear. A chronic high phosphate diet (HPD) in mice increases serum levels of phosphate and fibroblast growth factor 23 (FGF23) which is associated with progressive tubule damage and fibrosis. We hypothesized that chronic HPD induces TLS in the kidneys and thereby promotes progressive kidney injury. After only 2 months, mice on HPD showed increased tubule damage accompanied by the formation of perivascular immune cell clusters of B and T cells in the corticomedullary zone and in the cortex. In addition, lymphatic vessels were observed, accompanied by increased expression of venous markers and cell adhesion molecules. Further analyses showed a time-dependent induction of the immun

SUBMITTER: Weingartner N 

PROVIDER: S-EPMC12700132 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature