Urinary Sodium-Potassium Ratio and Cataract Risk: Insights From the NHANES 2003-2006 and Mendelian Randomization Analyses.

ABSTRACT:

Purpose

This study was based on the National Health and Nutrition Examination Survey (NHANES) and Mendelian randomization (MR) to explore the link between cataract and urinary sodium-potassium ratio (Na/K) ratio.

Methods

This study included 3,482 subjects from the 2003 to 2006 survey, with 305 cataract patients and 3177 controls. Baseline characteristics were analyzed using weighted χ2 or t-tests. Three models and stratified analyses assessed the association between Na/K ratio and cataracts. Receiver operating characteristic (ROC) curves and a k-nearest neighbor (KNN) model were used to evaluate the predictive value of the Na/K ratio for cataracts. MR analysis was conducted to explore the causal relationship between Na/K ratio and cataracts.

Results

The Na/K ratio was

SUBMITTER: Yanan L 

PROVIDER: S-EPMC12700177 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature