Synthesis, photochemical and biological evaluation of novel photoswitchable glycomimetic ligands of <i>Pseudomonas aeruginosa</i> LecB.

ABSTRACT: Bacterial multidrug resistance (MDR) poses a major threat to global health. The continued use of antibiotics, combined with genetic variations and exposure to nosocomial infections, has led to the selection and spread of multidrug-resistant bacteria. In recent years, photopharmacology has emerged as a strategy to combat MDR by enabling precise, light-controlled spatiotemporal modulation of the biological activity of photo-switchable compounds. Among different microbial species, Pseudomonas aeruginosa is a prominent bacterium involved in acute and chronic lung infections, posing a significant health concern, particularly among hospitalized and immunocompromised patients. The bacterium's capacity to form biofilms, a key factor in the development of MDR, is closely linked to the activi

SUBMITTER: Bhattacharya S 

PROVIDER: S-EPMC12700220 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature