Acute Respiratory Distress Syndrome Molecular Phenotypes Have Distinct Lower Respiratory Tract Transcriptomes.

ABSTRACT: Rationale: Two molecular phenotypes of the acute respiratory distress syndrome (ARDS) with divergent clinical trajectories and responses to therapy have been identified. Classification as "hyperinflammatory" or "hypoinflammatory" depends on plasma biomarker profiling. Limited data are available about the differences in the pulmonary biology of the molecular phenotypes. Objectives: To identify differences in the pulmonary biology of ARDS molecular phenotypes Methods: We compared tracheal aspirate gene expression between hyperinflammatory and hypoinflammatory phenotypes in bulk RNA sequencing (RNASeq) from coronavirus disease (COVID-19) and non-COVID-19 ARDS and single-cell RNASeq from non-COVID-19 ARDS. In a subset of subjects, we also compared plasma proteomic data.

SUBMITTER: Sarma A 

PROVIDER: S-EPMC12700240 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature