Assessment of Respiratory Mechanics and Inspiratory Effort During Spontaneous Breathing Trials to Predict Extubation Failure in High-Risk Patients.

ABSTRACT: Rationale: Conventional parameters to determine the success of spontaneous breathing trials (SBTs) may fail to detect impending respiratory distress. Objectives: To assess whether SBT-induced changes in respiratory system compliance, inspiratory effort, and respiratory drive measured as occlusion pressure during the first 100 milliseconds (P0.1), all assessed noninvasively through airway occlusions, are associated with extubation outcomes. Methods: We conducted a multicenter study on patients at high risk of extubation failure who successfully passed a 30-minute SBT on the basis of conventional parameters. The SBT was reproduced using a specific ventilator immediately before extubation to continuously monitor respiratory system compliance, inspiratory effort, and P0.1.

SUBMITTER: Murgolo F 

PROVIDER: S-EPMC12700285 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature