Temporal trends in tuberculosis and time from enrolment in care to antiretroviral therapy initiation: A multicountry cohort study from Latin America.

ABSTRACT:

Background

HIV treatment guidelines have evolved to recommend rapid antiretroviral therapy (ART) initiation. Data on the impact of these changes in the Americas region are scarce.

Methods

This study included data from CCASAnet sites in Brazil, Haiti, Honduras, Mexico, and Peru. ART-naïve adults who started ART from 2006 to 2022 were included. Trends in CD4 count, tuberculosis (TB), and treatment initiation were described using cumulative probability and logistic and Cox regression models.

Findings

Total 29,881 PLWH met inclusion criteria; 2179 (7.3%) were diagnosed with prevalent TB and 379 (1.2%) with incident TB within six months after ART initiation. For individuals without TB, enrolment CD4 count increased from 160 to 320 cells/mm³. Over the study perio

SUBMITTER: Shepherd BE 

PROVIDER: S-EPMC12700299 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature