Crystallization-Induced Diastereomer Transformations of Brominated Arylacetic and Arylpyruvic Acids.

ABSTRACT: Enantiopure halogenated carboxylic acid derivatives are valuable building blocks for the synthesis of stereochemically complex and pharmaceutically relevant molecules. We report the crystallization-induced diastereomer transformations (CIDTs) of diastereomeric salt pairs of α-bromo arylacetic and β-bromo arylpyruvic acids. The salts were obtained with high diastereoselectivities via direct filtration of the reaction mixture, and a salt break facilitated recovery of the enantiopure acids and chiral amines in high yields. The former react to produce synthetically useful enantiopure building blocks.

SUBMITTER: Angles SN 

PROVIDER: S-EPMC12700324 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature