Variability in intrinsic promoter strength underlies the temporal hierarchy of the Caulobacter SOS response induction.

ABSTRACT: Bacteria encode for gene regulatory networks crucial for sensing and repairing DNA damage. Upon exposure to genotoxic stress, these transcriptional networks are induced in a temporally structured manner. A case in point is of the highly conserved SOS response that is regulated by the LexA repressor. Studies have proposed that affinity of LexA towards promoters of SOS response genes is the primary determinant of its expression dynamics. Here, we describe an additional level of regulation beyond LexA box properties that modulates the SOS response gene expression pattern. Using transcriptomic analyses, we reveal a distinct temporal hierarchy in the induction of SOS-regulated genes in Caulobacter crescentus. We observe that LexA box properties are insufficient in predicting the temporal hierar

SUBMITTER: Kamat A 

PROVIDER: S-EPMC12700426 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature