Blood RNA biomarkers and a point-of-care elastase assay for detecting host immune activation in suspected sepsis: Trajectory matters.

ABSTRACT:

Introduction/hypothesis

The chances of survival from sepsis are improved by early diagnosis and treatment. In the prospective SENSOR study, RNA biomarkers of innate immune neutrophil activation were examined in emergency department (ED) patients triggering an automated sepsis alert. We hypothesized that higher levels of blood RNA biomarkers related to neutrophil activation would be associated with progression to more severe forms of sepsis.

Methods

Adult patients in the ED triggering a sepsis alert were consented, enrolled, and study samples were obtained during the ED visit. Additionally, study samples were collected from a convenience sample of 16 adult non-ED controls and 8 other adults with self-described infectious illnesses. Blood samples were drawn in RNA preservative

SUBMITTER: Lafleur JE 

PROVIDER: S-EPMC12700442 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature