Exploring Neuroinflammation and Its Role in Postoperative Cognitive Dysfunction following Spine Surgery.

ABSTRACT:

Introduction: Progress in spine surgery has significantly improved the safety of procedures for older patients with disabling spine disease. However, postoperative cognitive dysfunction (POCD) remains a concern due to their link with poorer outcomes and higher long-term care risk. This study aimed to determine if pro-neuroinflammatory states accelerate neurodegeneration, contributing to POCD development, and explore whether specific biomarkers could predict POCD risk.

Methods

Patients (aged ≥ 60 years) scheduled for elective spine surgery between February 2018 and March 2020 were enrolled. Biomarkers tested included IL-6, C-reactive protein, S100 calcium-binding protein β, brain-derived neurotrophic factor, serum neurofilament light chain protein (sNFL), gasdermin D, and soluble

SUBMITTER: Ruhnau J 

PROVIDER: S-EPMC12700582 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature