Efficacy of Double Trigger versus hCG Trigger Alone in GnRH-Antagonist Cycles: A Systematic Review and Meta-Analysis.

ABSTRACT:

Introduction

Triggering final oocyte maturation is a critical step in in vitro fertilization-embryo transfer (IVF-ET), especially for optimizing outcomes in patients with poor ovarian response or low oocyte maturation. The double trigger protocol, combining a GnRH agonist with human chorionic gonadotropin (hCG), has been proposed to enhance oocyte quality and improve reproductive outcomes compared to hCG alone. Our review aimed to evaluate the efficacy of the double trigger compared to hCG-only trigger on reproductive outcomes in patients undergoing IVF-ET.

Methods

A systematic review and meta-analysis were conducted using PubMed, Scopus, and Google Scholar up to June 15, 2025. Studies comparing double trigger to hCG-only trigger were included. Outcomes such as the number of

SUBMITTER: Syam HH 

PROVIDER: S-EPMC12700583 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature