Eosinophilic Esophagitis as a Complex Th2 Inflammatory Disease: Results of a Prospective Long-Term Study in Children.

ABSTRACT:

Introduction: While the eosinophilic esophagitis (EoE) has become the second most common disease entity causing esophageal dysfunction, there is currently a lack of data reporting on pediatric EoE from Germany. This monocentric longitudinal study seeks to fill this gap by investigating treatment success, atopic co-morbidities, and potential blood parameters in a real-world setting.

Methods

This study analyzed data on children with EoE (n = 50), gastroesophageal reflux disease (GERD, n = 13), and controls (n = 5). Evaluated characteristics included clinical manifestations, atopy, and treatment success during disease progress. We defined the primary endpoint as histological remission in all esophageal locations (proximal, mid, distal). Secondary endpoints were histological-clinical

SUBMITTER: Degen S 

PROVIDER: S-EPMC12700584 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature