Mild Variations in Thyroid Hormone Serum Concentrations Show Associations with the ET 6-6-R Developmental Test: Results from a Population-Based Pediatric Cohort in Germany.

ABSTRACT:

Introduction

Thyroid hormones are essential for child development, and untreated hypothyroidism can lead to severe adverse effects, including mental retardation. However, whether thyroid hormone variation within the normal range affects developmental tests is not known. Thus, we aimed to investigate associations between physiological variations in thyroid hormone levels and the results of developmental tests in healthy children.

Methods

This study included 946 children who completed the Bayley Scales of Infant and Toddler Development (BSID) III and 1,467 children who completed the developmental test for children from 6 months to 6 years old (ET 6-6-R). Using regression models, we assessed the association between TSH, FT3, and FT4 and test results as outcomes. In addition, we

SUBMITTER: Keil EL 

PROVIDER: S-EPMC12700585 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature