Myeloperoxidase gene knockout causes local inflammation and dysbiosis in the murine gut.

ABSTRACT: Myeloperoxidase (MPO), predominantly expressed in neutrophils, catalyzes the production of hypochlorous acid (HOCl) that plays an integral role in the host defense against invading pathogens. However, little is known about its role in maintaining normal gut microbiome and function. Here, we report the comparisons of inflammation and microbiome in the intestines of WT and MPO^-/- mice. Immune cell profiling demonstrated that the MPO^-/- mice had significantly more neutrophils and T cells in their intestinal mucosae and significantly more fecal calprotectin as compared to the WT mice. Fluorescent dextran permeability of the bowel showed no difference between the two strains of mice. Carmine Red transit demonstrated that the MPO^-/- intestines had slower movement

SUBMITTER: Wang JJ 

PROVIDER: S-EPMC12700598 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature