A New Radiotranscriptomic Approach to Analyze Combined Sets of T3b Stage-Specific Genes and Radiomic Features in Prostate Cancer.

ABSTRACT:

Background

Current clinical staging of prostate cancer (PCa) using the tumor-node-metastasis (TNM) system and serum biomarkers remains limited in distinguishing locally advanced (T3b) PCa from organ-confined (T2c) disease.

Aims

Building on our previous biomarker discovery in differentiating PCa from that of benign prostatic hyperplasia, this study pioneers a radiotranscriptomic model to distinguish T3b stage PCa from T2c stage PCa by integrating contrast-enhanced ultrasound (CEUS) radiomics with stage-specific transcriptomic signatures, addressing a critical knowledge gap in precision staging.

Methods and results

This prospective study was approved by the review board of Chinese PLA General Hospital (S2021-565-01), and all participants provided written informed consen

SUBMITTER: Yang Q 

PROVIDER: S-EPMC12700717 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature