Thalamo-frontal functional connectivity patterns in Tourette Syndrome: Insights from combined intracranial DBS and EEG recordings.

ABSTRACT: Thalamic deep brain stimulation (DBS) has shown clinical improvement for patients with treatment-refractory Tourette Syndrome (TS). Advancing DBS for TS requires identifying reliable electrophysiological markers. Recognising TS as a network disorder, we investigated thalamo-cortical oscillatory connectivity by combining local field potential (LFP) recordings from the DBS thalamic target region using the Percept^TM PC neurostimulator with high-density EEG in eight male TS patients (aged 27-38) while stimulation was off. We identified a spatially and spectrally distinct oscillatory network connecting the medial thalamus and frontal regions in the alpha band (8-12 Hz), with functional connectivity strength negatively correlated with TS symptom severity. Moreover, reduced thalamo-fro

SUBMITTER: Wehmeyer L 

PROVIDER: S-EPMC12700786 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature