Non-Clozapine interventions in treatment-resistant schizophrenia: a systematic review and meta-analysis.

ABSTRACT:

Background and hypothesis

Clozapine is the only licensed pharmacotherapy for treatment resistant schizophrenia (TRS), but in some cases is not a suitable treatment option. A review of the efficacy of non-clozapine interventions in TRS may help inform clinical decision making when clozapine treatment is not feasible.

Study design

A systematic review and meta-analysis was performed investigating the efficacy of non-clozapine augmentation of antipsychotic treatment in TRS on positive, negative, and total symptoms. The review protocol is registered at PROSPERO (ID: CRD42023418053). PsycInfo, PubMed and EMBASE were searched up until July 2023. Cochrane Risk of Bias tool (v2) was used to assess study quality. Data were pooled using a random-effects model for each class of interven

SUBMITTER: Carr R 

PROVIDER: S-EPMC12700803 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature