Extracellular matrix dysfunction and synaptic alterations in schizophrenia.

ABSTRACT: Schizophrenia is a complex disorder with strong evidence implicating neurodevelopmental abnormalities in its pathophysiology. Olfactory neuroepithelial cells from patients provide a unique platform for studying neurodevelopmental processes. These cells can be cultured into neurospheres and differentiated into neurons, allowing the study of patient-specific alterations related to the disorder. In this study, we utilized olfactory neuroepithelial cells from patients with schizophrenia and controls to explore putative neurodevelopmental dysregulations. RNA-sequencing of neurospheres transcriptome revealed significant alterations in extracellular matrix-related gene expression, suggesting extracellular matrix dysregulation as an underlying contributor to schizophrenia etiopathogenesis. Upon di

SUBMITTER: Unzueta-Larrinaga P 

PROVIDER: S-EPMC12700823 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature