Developmental modulation of schizophrenia risk gene methylation in offspring exhibiting cognitive deficits following maternal immune activation.

ABSTRACT: Maternal infection during pregnancy has been shown in epidemiological studies to increase the risk of neurodevelopmental disorders, like schizophrenia, in the developing fetus. Epigenetic mechanisms are thought to play a crucial role in linking maternal immune activation (MIA) to a higher risk of schizophrenia in offspring by disrupting normal brain development. However, our knowledge of how these epigenetic mechanisms are altered and contribute to abnormal neurodevelopment remains limited. This lack of understanding has slowed progress in identifying therapeutic targets in particular for cognitive symptoms of neurodevelopmental disorders. Focusing on the cortex of offspring exposed to MIA who showed cognitive impairments, at both prenatal and postnatal stages, here we measured tissue conc

SUBMITTER: Woods RM 

PROVIDER: S-EPMC12700827 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature