Engineering filamentous potato virus X as a platform nanotechnology for nucleic acid gene delivery.

ABSTRACT: Nucleic acid therapeutics and gene delivery platforms have the potential to change the way we treat disease, enabling precision medicine. Advances in biotechnology have allowed for production of virtually any functional protein or peptide in the human body through the introduction of various classes of RNA, including regulatory and coding RNAs (e.g., mRNA) in the form of linear or circular RNA (circRNA). To be effective, nucleic acid therapeutics require safe, stable, and efficient delivery vehicles that protect the otherwise labile cargo from degradation, promote cellular uptake, and facilitate payload release. Lipid nanoparticles (LNPs) have enjoyed recent clinical success for the delivery of mRNA to combat disease - especially against coronavirus 2019 (SARS CoV-2) and, more recently, ag

SUBMITTER: Duoto B 

PROVIDER: S-EPMC12700909 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature