Dapagliflozin treatment ameliorates oxidative stress, apoptosis and inflammation in tenofovir-induced nephrotoxicity in rats.

ABSTRACT: Tenofovir disoproxil fumarate is a widely prescribed component in antiretroviral therapy regimes frequently associated with nephrotoxicity. Dapagliflozin, an SGLT2 inhibitor, is primarily used as a hypoglycemic agent but is increasingly recognized for its pleiotropic protective effects. To investigate whether dapagliflozin could mitigate tenofovir-induced nephrotoxicity, Wistar rats were randomly assigned to four groups: Control- received a standard diet for 45 days, TDF- received a standard diet added with tenofovir (300 mg/kg food) for 45 days, DAPA- received a standard diet for 45 days added with dapagliflozin (20 mg/kg food) in the last 15 days, and TDF + DAPA- received a standard diet added with tenofovir for 45 days and dapagliflozin in the last 15 days. Dapagliflozin administration

SUBMITTER: Dos Santos VA 

PROVIDER: S-EPMC12700963 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature