Real-world efficacy and safety of pembrolizumab plus lenvatinib in patients with metastatic renal cell carcinoma: a multi-institutional retrospective study.

ABSTRACT: Despite the potential of pembrolizumab and lenvatinib combination therapy in treating metastatic renal cell carcinoma (mRCC), real-world evidence on its efficacy and safety remains limited. We retrospectively analyzed data from 118 patients with mRCC who initiated pembrolizumab plus lenvatinib as first-line therapy between August 2022 and March 2024. Patient characteristics, treatment outcomes, and adverse events were evaluated. Oncological outcomes were stratified following the International Metastatic RCC Database Consortium risk classification. The objective response and disease control rates were 69.5% and 98.5%, respectively. Median progression-free survival (PFS) was 26.8 months (95% confidence interval (CI), 23.5-27.8)), whereas the median overall survival (OS) was not reached (95%C

SUBMITTER: Kato T 

PROVIDER: S-EPMC12700968 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature