Bridging thrombolysis versus direct thrombectomy in acute ischemic stroke with large vessel occlusion: a network meta-analysis.

ABSTRACT:

Background

Endovascular treatment (EVT) is the standard of care for acute ischemic stroke caused by large-vessel occlusion (AIS-LVO). The benefit of intravenous thrombolysis (IVT) before EVT remains uncertain, particularly for patients presenting directly to EVT-capable centers. Tenecteplase, with simpler administration and potential to improve early reperfusion, may offer an alternative to alteplase. This network meta-analysis evaluates the efficacy and safety of bridging therapy with different doses of alteplase or tenecteplase compared with direct EVT within 4.5 h of stroke onset.

Methods

A systematic literature search was conducted across the MEDLINE, Embase, and Cochrane Central Register of Controlled Trials databases from their inception through September 20, 2025, to

SUBMITTER: Huang J 

PROVIDER: S-EPMC12700989 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature