Synthesis, molecular docking, ADMET studies and biological evaluation of fused pyrazolopyridopyrimidine derivatives as antioxidant and antimicrobial agents.

ABSTRACT: This study describes the design, synthesis, and biological evaluation of fused pyrazolopyridopyrimidine analogues as potential antimicrobial and antioxidant agents. The chemical structures of the newly synthesized compounds were confirmed by elemental analyses and spectroscopic methods. The compounds were screened for antimicrobial activity against Escherichia coli ATCC 25,915, Staphylococcus aureus ATCC 25,923, Enterococcus faecalis ATCC 29,212, Pseudomonas aeruginosa ATCC 10,145, and Streptococcus mutans ATCC 25,175. Compound 7 exhibited pronounced inhibitory effects. Evaluation of antioxidant potential using the DPPH radical scavenging assay revealed that compound 15 displayed superior activity, with inhibition values of 44.44 ± 0.80%, 16.50 ± 0.90%, and 0.0% at concentrations of 2.0, 1

SUBMITTER: Khalaf H 

PROVIDER: S-EPMC12701012 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature