Circulating Extracellular Vesicles from Heart Failure Patients Inhibit Human Cardiomyocyte Activities.

ABSTRACT: Extracellular vesicles (EVs) have been implicated in cardiac remodeling during heart failure (HF). However, the role of circulating EVs (CEVs) in the process of HF is poorly understood. To elucidate the molecular mechanism associated with CEVs in the context of HF, the proteome of 4D label-free EVs from plasma samples was identified. Among the identified proteins, 6 exhibited upregulation while 9 demonstrated downregulation in CEVs derived from HF patients (HCEVs) compared to healthy controls (NCEVs). Our results showed that up-regulated proteins mainly participate in the primary metabolic, glycerolipid metabolic processes, oxidation-reduction process, and inflammatory amplification. In contrast, the down-regulated proteins influenced cell development, differentiation, and proliferation. C

SUBMITTER: Zhen K 

PROVIDER: S-EPMC12701023 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature