Impact of enteral Ecoimmunonutrition on immunological response, nutritional status and tolerance to treatment in gastrointestinal malignancy patients receiving chemotherapy.

ABSTRACT:

Purpose

Gastrointestinal (GI) malignancies are major contributors to global cancer-related mortality, with many patients experiencing severe nutritional decline and immune suppression due to chemotherapy. Enteral immunonutrition (EIN), which includes immune-modulating nutrients, has shown promise in improving nutrition, reducing chemotherapy-related side effects, and enhancing immune function, but its role in advanced GI cancer patients undergoing chemotherapy is not well-studied.

Methods

This randomized, controlled study involved 28 patients with advanced GI malignancies, assigned to either standard nutrition or EIN for 42 days. Key measures included nutritional status, immune markers, quality of life (QoL), and chemotherapy-related toxicities. The study also used a preclin

SUBMITTER: Zhi J 

PROVIDER: S-EPMC12701029 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature