Streptococcus gordonii type VII secretion system substrate EsxA induces neutrophil extracellular trap formation in infective endocarditis.

ABSTRACT: Type VII secretion system (T7SS) substrate EsxA contributes to the pathogenesis of several Gram-positive bacteria, but its role in viridans streptococci-induced infective endocarditis (IE) remains unclear. Genomic analysis of the Streptococcus gordonii DL1 strain identified a genetic locus encoding five T7SSb core machinery proteins (EsaA, EssA, EsaB, EssB, and EssC) and one substrate, EsxA. T7SSb mediates EsxA secretion, as evidenced by reduced secretion in the essC-deleted mutant and restoration upon complementation. In a rat model of IE, the esxA-deficient strain shows lower survival in circulation and reduced formation of vegetation, suggesting a role for EsxA in IE pathogenesis. Using a transwell system, molecules secreted from wild-type S. gordonii DL1 can induce the release of neutr

SUBMITTER: Hsu CC 

PROVIDER: S-EPMC12701049 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature