Relationships among dietary patterns and heterogeneous biological aging at system and organ-specific levels and mortality risks.

ABSTRACT: This study utilized data from the National Health and Nutrition Examination Survey (NHANES), to train mortality prediction-based phenotypic ages (PhenoAge [systemic] and organ-specific ages [cardiovascular, kidney, liver, and musculoskeletal]) from NHANES-III, and applied it in the continuous NHANES. Weighted linear regression analyses revealed significant associations between five diet scores-Healthy Eating Index 2020, Alternate Healthy Eating Index, Dietary Approaches to Stop Hypertension, Alternate Mediterranean Diet Score, and Dietary Inflammatory Index-derived from 24-hour diet recalls and accelerations in biological ages, encompassing both phenotypic and epigenetic measures (GrimAge2 and DunedinPoAm). Reduced rank regression was used to derive five aging-related diet scores that cons

SUBMITTER: Xu X 

PROVIDER: S-EPMC12701052 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature