A Multi-Faceted Approach to Explore the Role of Inflammatory CAFs, Providing Prognostic Value and Therapeutic Implications in Lung Adenocarcinoma.

ABSTRACT:

Background

Lung adenocarcinoma (LUAD) is the most common subtype of lung cancer, where its complex tumor microenvironment (TME) significantly influences disease progression and treatment response. Inflammatory cancer-associated fibroblasts (iCAFs), as a key component of the TME, can promote tumor immune evasion and drug resistance. However, the characteristics of iCAFs in LUAD and their clinical significance have not been fully elucidated.

Methods

The bulk RNA data and scRNA-seq data of LUAD from public databases were integrated to identify and characterize iCAFs subsets and screen their feature genes. iCAF-based signature (ICAFBS) was generated using multiple machine learning algorithms and confirmed in multiple independent cohorts. The relationship between ICAFBS and immun

SUBMITTER: Zhou X 

PROVIDER: S-EPMC12701138 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature