CD154 Restricts Helminth-Induced Macrophage Polarisation and Proliferation While Promoting Tissue Residence.

ABSTRACT: CD154 (CD40L) is of central importance in effector responses mediated by classically activated macrophages. However, there is limited information on the impact of CD154 on macrophage responses in type 2 contexts, characterised by IL-4-induced polarisation and proliferation. CD154 restricts the polarisation and proliferation of peritoneal cavity macrophages in response to exogenous IL-4. Here we address the impact of CD154 on peritoneal macrophages during infection of mice with the intestinal helminth Heligmosomoides polygyrus. This strictly enteric nematode causes recruitment of Th2 cells and macrophages to the peritoneal cavity alongside type 2 polarisation and proliferation of recruited and resident macrophages. Nine days post-infection, there was an increase in the expression of cell-su

SUBMITTER: Suarez-Martins M 

PROVIDER: S-EPMC12701298 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature