Red Wine May Mitigate the Risk of Intracerebral Hemorrhage by Preventing Hypertension-A Mendelian Randomization Study Combining CHARLS.

ABSTRACT: Although alcohol is viewed as a risk factor for intracerebral hemorrhage, the causal relationship between different types of alcoholic beverages and intracerebral hemorrhage remains unclear, representing a significant gap in the field of intracerebral hemorrhage prevention. This study aims to fill this gap by investigating how daily drinking habits can help prevent intracerebral hemorrhage. Alcohol, red wine, and white wine were selected to conduct two-sample Mendelian randomization analyses to investigate their associations with intracerebral hemorrhage. Positive results (alcohol, red wine) were further analyzed using multivariable Mendelian randomization to distinguish independent effects. Additionally, hypertension, a risk factor for intracerebral hemorrhage, was utilized for mediation

SUBMITTER: Zhang F 

PROVIDER: S-EPMC12701324 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature