Cognitive profiles at presentation and subsequent cognitive decline and quality of life in Parkinson's disease.

ABSTRACT:

Introduction

Currently, our ability to predict cognitive decline in Parkinson's disease is limited.

Methods

In 234 dementia-free PD patients, cognitive profiles at baseline were determined using cluster analysis and longitudinal associations with global cognitive z-score, health-related quality of life (HR-QoL), caregiver burden, and risk of reliable cognitive change (RCC) were tested.

Results

Participants fell into four cognitive profiles at baseline: normal cognition (n = 108), memory impairment (n = 47), memory and executive function impairment (n = 59), and global cognitive impairment (n = 20). After adjusting for the severity of cognitive impairment, only the memory impairment cluster showed a higher risk of RCC. Baseline cognitive profiles did not predict differ

SUBMITTER: Mirza SS 

PROVIDER: S-EPMC12701370 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature