Enrichment of patients with concomitant limbic-predominant age-related TDP-43 encephalopathy (LATE) on the Alzheimer's disease continuum using hippocampal volume.

ABSTRACT:

Introduction

Clinical overlap between Alzheimer's disease (AD) and limbic-predominant age-related transactive response DNA binding protein 43 (TDP-43) encephalopathy (LATE), combined with the absence of validated in vivo biomarkers, complicates identification of mixed AD/LATE pathology. We labeled individuals along the AD continuum with suspected concomitant LATE using the lower quartile hippocampal volume (HV) cut-off and examined associated atrophy and cognitive profiles.

Methods

We studied cognitively impaired (CI) Alzheimer's Disease Neuroimaging Initiative (ADNI) participants with T1-magnetic resonance imaging (MRI) and amyloid- and tau-positron emission tomography (PET). Participants were classified into suspected (s) AD+sLATE-, AD-sLATE+, or AD+sLATE+ based on amyloid

SUBMITTER: Mundada NS 

PROVIDER: S-EPMC12701520 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature