Dietary antioxidant capacity, flavonoid subclasses, and metabolic dysfunction-associated fatty liver disease in overweight and obese youth.

ABSTRACT:

Background

Metabolic dysfunction-associated fatty liver disease (MAFLD) is a growing public health concern among children and adolescents with overweight and obesity. Diet quality, particularly antioxidant intake, may play a role in hepatic metabolic regulation. This study investigated the association between dietary total antioxidant capacity (DTAC) and MAFLD, and examined the mediating role of flavonoid subclasses.

Methods

In this cross-sectional study, 505 overweight and obese Iranian children and adolescents aged 7-18 years were recruited. DTAC was estimated using a validated 147-item food frequency questionnaire and the ferric reducing antioxidant power (FRAP) method. MAFLD was diagnosed via ultrasonographic evidence of hepatic steatosis in combination with overweight/o

SUBMITTER: Kamrani F 

PROVIDER: S-EPMC12701603 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature