Association Between Iron Overload and the Risk of Ocular Hypertension, Primary Open-Angle Glaucoma, and Normal-Tension Glaucoma.

ABSTRACT:

Purpose

To investigate whether iron overload is associated with increased risk of ocular hypertension (OHT), primary open-angle glaucoma (POAG), and normal-tension glaucoma (NTG).

Methods

A retrospective cohort study was conducted using the TriNetX multinational database. Patients ≥ 40 years old without prior glaucoma were classified into iron overload and non-iron overload groups. Propensity score matching (1:1) was applied to balance demographics, comorbidities, and medication use. Cox proportional hazards regression estimated hazard ratios (HRs) and 95% confidence intervals (CIs). Kaplan-Meier analyses evaluated cumulative incidence over 5 years.

Results

Among 63,577 matched pairs, iron overload was significantly associated with elevated risks of OHT (HR = 1.32; 95

SUBMITTER: Tsai CY 

PROVIDER: S-EPMC12701610 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature